Caister Academic Press

Topoisomerase

Next-generation Sequencing and Bioinformatics for Plant Science
Edited by: Vijai Bhadauria
Review of next-generation sequencing and bioinformatics and applications in plants, in particular crop yield, drought tolerance and disease resistance.
Topoisomerase alters the supercoiling of DNA. Topoisomerase cuts the DNA. Topoisomerase type I cuts one strand and topoisomerase type II cuts both strands. Topoisomerase regulates DNA supercoiling. Topoisomerase aids the transcription and replication of DNA. As well as topoisomerase I and topoisomerase II, there is topoisomerase III and topoisomerase IV.

Topoisomerase

Topoisomerase: Topoisomerase is an enzyme that alters the supercoiling of double-stranded DNA. Topoisomerase acts by transiently cutting one or both strands of the DNA. Topoisomerase type I cuts one strand whereas topoisomerase type II cuts both strands of the DNA. Topoisomerase relaxes the coil and extends the DNA molecule. Topoisomerase helps regulate DNA supercoiling. Topoisomerase aids the transcription and replication of DNA.
As well as topoisomerase I and topoisomerase II, there is topoisomerase III and topoisomerase IV. Topoisomerase III may regulate recombination. Topoisomerase IV regulates the segregation of newly replicated chromosomes.

Molecular Biology Resources

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The Protocols Gateway
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Further reading